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& Zhang, F

103,104,105 These toxic side effects are caused, at least in part, by the synergistic activity of glutaminase in ASNase

Glutathione has many important functions, including: making DNA, the building blocks of proteins and cells supporting immune function breaking down some free radicals helping certain enzymes function regenerating vitamins C and E assisting regular cell death (a process known as apoptosis) It also helpsthe liver and gallbladder deal with fats Researchers have found links between low levels of glutathione and some diseases

Glutathione helps neutralise these, maintaining balance

Mutant -synuclein permeabilizes these vesicles causing leakage of the dopamine into the cytoplasm where it autooxidizes producing hydrogen peroxide, superoxide molecules, and toxic dopamine-quinone species creating oxidative stress conditions [122]