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Targeting zonulin attenuates arthritis Next, and most importantly, we directly blocked zonulin by larazotide acetate (AT-1001), a first-in-class TJ regulator, currently used in phase III clinical trials for celiac disease 29

Waters et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Liu, Y

Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski J, Harrison DG (2008) Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease

PubMed, Stappers, M

higher doses may be required for men with severe oxidative stress or inflammatory conditions