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DA has been found to promote cellular iron accumulation and enhance oxidative stress responses in macrophages [108]

10.1016/s1535-6108(03)00050-3 43 EgolfS.ZouJ.AndersonA.SimpsonC

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Therefore, the inability to maintain NRF2 protein expression is directly associated with poor prognosis in clinical patients diagnosed with lung cancer.16,19,20 The Cancer Genome Atlas (TCGA) data showed that approximately 30% of human lung cancers harbor mutations in KEAP1 or NFE2L2 genes that ultimately lead to NRF2 stabilization and upregulation of its downstream genes.21,22 NRF2 signaling pathway in oncogenesis Loss of KEAP1 function leads to defective activation of the NRF2 signaling pathway in NSCLC cells, resulting in resistance to chemotherapeutic agents.13 The inability of KEAP1 to bind NRF2 due to both mutations results in increased NRF2 accumulation and downstream gene transcription

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