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This leads to a number of secondary motor and non-motor symptoms 9,11 such as neuropsychiatric disorders (anxiety and depression), autonomic dysfunction (constipation), sleep abnormalities (insomnia), olfaction and visual disorders, and cognitive decline including dementia 12,13

10.1038/372186a0 Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, et al .: Disruption of IRS-2 causes type 2 diabetes in mice

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