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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

Peng H, Cheng Q, Chen J, Wang Y, Du M, Lin X, et al

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The most common comorbidities are listed in Table 2

10.3389/fimmu.2022.831168 264 YangK.VelagapudiS.AkhmedovA.KralerS.Lapikova-BryhinskaT.SchmiadyM

Reducing the burden of difficult-to-treat major depressive disorder: revisiting monoamine oxidase inhibitor therapy