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These enzymes are rate-limiting in the production of ceramides, which constitute approximately fifty percent of the intercellular lipid matrix and are absolutely essential for maintaining barrier impermeability

Although endometriosis can appear benign and its symptoms usually disappear in post-menopausal women, resultant infertility and severe, disabling pain significantly diminish patients quality of life3,4

10.1371/journal.pone.0036739 50 DheyauldeenS.AhmedE

10.1007/s00726-006-0416-9 Amino Acids 168 SuzukiH.YamadaC.KijimaK.IshiharaS.WadaK.FukuyamaK.et al (2010)

Ranke MB, Wit JM

Wang W, Hu Y, Yang C, Zhu S, Wang X, Zhang Z, et al