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& Catalano, D

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

While App knockin mouse shows no significant neurodegeneration and neuronal loss, it shows synaptic loss and reduction of a part of neuronal cells including active place cells around A plaques 41,60

GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

It says it will remove products from the market if they claim to treat or change how the body works if they are not licensed under the Human Medicines Regulations Act 2012, and that it strongly advises against purchasing and using unauthorised medicinal products - "particularly those promoted on social media".

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