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Both excess copper and copper deficiency lead to severe neurological consequences as exemplified, respectively, by Wilson and Menkes diseases

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As a result, copper accumulates to toxic levels that can damage tissues and organs, particularly the liver and brain

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It is called NAFL if it is only steatosis (fatty liver) and NASH if there is severe inflammation and liver cell damage (steatohepatitis)

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For a more detailed discussion of the calculation of the hospital-specific rates, we refer readers to the FY 1984 IPPS interim final rule (48 FR 39772)

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