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Senescent cells accumulate over time, meaning that senolytic treatment may need to be repeated periodically, raising concerns about chronic drug administration and potential cumulative side effects.122 Variability in Response and Individual Differences: Senescence is influenced by genetic factors, lifestyle, and environmental exposures, meaning that not all individuals may respond equally to senolytic therapy.123 Age-related changes in metabolism and drug clearance could also impact the effectiveness and safety of senolytics in older adults.124 Dosing and Treatment Scheduling: Determining the ideal dose and treatment schedule for senolytic therapies is complex

As a result, there is an overexpression of p16 and p21 [90]

Current evidence regarding toxicity from GHK-Cu is limited, but factors such as product concentration, frequency of use, and underlying health conditions (like Wilson's disease) may influence risk considerations

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