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Tyrosinase is produced only by melanocyte cells

Commonly a chelating agent will mobilize the most readily available metals first, typically in the plasma, kidney, liver and then to a lesser extent bone and central nervous system

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Such long-term consequences include increased risk of cardiovascular complications, hyperalgesia, cognitive deficits, and more

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Sullivan L.B., Gui D.Y., Hosios A.M., Bush L.N., Freinkman E., Vander Heiden M.G

76 The JAK/STAT pathway plays a significant role in the pathogenesis of CRS associated with CAR-T therapy, with appropriate activation enhancing the antitumor activity of CAR T-cells and overactivation contributing to CRS