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Description
It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
Research has investigated the mechanisms by which NNMT inhibition might increase energy expenditure, potentially through effects on mitochondrial function or uncoupling protein expression
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doi: 10.1021/acs.jmedchem.7b01422 103 ChenDLiLDiazKIyamuIDYadavRNoinajNet al
[DOI] [PubMed] [Google Scholar] 71.Rozgony N.R., Fang C., Kuczmarski M.F., Bob H
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