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GH exerts autocrine/paracrine effects by binding to GHR in the same or a neighboring cell surface and initiating JAK2- and SRC-mediated signaling cascades, which decrease pro-apoptotic molecules (Bax and PPAR) and suppress caspase protein activation (Figure 4A)

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d) Adipocytes Adipocytes, particularly those in the omentuma primary metastatic site for ovarian cancerplay a significant role in tumor progression and drug resistance

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Like other transmembrane proteins, SLC7A11 protein is synthesized in endoplasmic reticulum (ER) and subsequently transferred to the Golgi apparatus by vesicular and ultimately functions on the cell membrane [20]

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