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This was first explored by Balthasar and colleagues, who in 2005 proved that specific inhibition of the IgG:FcRn interaction by use of a murine mAb (mouse IgG1, clone 4C9) with V regions specific for rat 2m generated by Bjorkman and colleagues could deplete endogenous IgG levels in rats [113, 114]

Science (2002) 297:3536.10.1126/science.1072994 42 LiptonSA

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Taken together, this report leads to the new question of why archaea more advanced than bacteria select the anionic FMN semiquinone

Enzymes involved in lipid metabolism may also be the appropriate target to prevent the formation of brain metastases, because oncogenic lipid signaling can promote the metastasis of breast tumor cells to the brain by supporting cell survival, migration, and invasion (154)

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