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Safety, Sourcing, and Why Medical Oversight Is Non-Negotiable BPC-157 has a strong safety record in animal studies notably, the lethal dose (LD1) has not been achieved across decades of preclinical research, and it has been used in human ulcerative colitis and multiple sclerosis trials without reported toxicity.6 But the absence of adverse events in animals does not translate directly to human safety, particularly at unregulated doses from unverified sources

The question of how BPC-157 modulates NO-associated signaling remains open