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Description
Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

Shaheen et al., 2020
doi: 10.1515/BC.2009.033 25

Clin Chem 44 : 825832 Robinson BH, Glerum DM, Chow W, Petrova-Benedict R, Lightowlers R, Capaldi R 1990 The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia

The spectrum of inflammatory responses
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