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Furthermore, ADSC-EV-enclosed cytokines such as osteoprotegerin (OPG) and miRNAs such as miR-21-5p and let-7b-5p have been reported to hamper osteoclastogenesis by downregulating genes associated with bone resorption, suggesting the potential therapeutic use of ADSC-EVs in the treatment of osteoporosis [107]

We further performed statistical analysis comparing the normalized total lipids and the ratio of newly synthesized lipids to total lipids, averaged across single-cell areas, between the control and GRN -KD groups (Fig

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