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Its unique profile makes it an attractive compound for exploring the therapy of metabolic disease and muscle aging, as well as evaluating the intricate links between metabolism, epigenetics, and tissue function 1-4

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Although this may offer systemic recovery and healing benefits, it introduces complexity in predicting responsesespecially in polypharmacy and comorbidity contexts

Their mechanisms of action are summarized in Figure 3 , and the classification, molecular targets, and known resistance mechanisms are listed in Table 1