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B12 deficiencies usually develop slowly, and symptoms might not show up fully for years

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When your body lacks adequate B12, you may experience symptoms such as persistent tiredness, weakness, numbness, or even memory issues

Springer Berlin Heidelberg, Berlin, Heidelberg, pp 319326 McEachran AD, Mansouri K, Newton SR et al (2018) A comparison of three liquid chromatography (LC) retention time prediction models