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Mild redness on the skin Slight itching or irritation Dryness or tight sensation Small bumps or rashes (rare) Increased sensitivity in sensitive skin

doi: 10.1038/s42255-018-0014-7 74 HabibNWoodCApostolovKBarkerWHershmanMAslamMet al

Kidney injury appears only as a secondary effect of dehydration from severe gut upset. Anti-drug antibodies form in roughly half to two-thirds of users but do not affect clearance, weight, or blood sugar. Benefits that look like side effects Tirzepatide lowers uric acid (about -0.7 to -1.0 mg/dL, mostly through weight loss) and lowers blood pressure

In astrocytes, Nrf2 activators promote the translocation of Nrf2 from the cytoplasm to the nucleus, where it binds to the antioxidant response element (ARE), upregulating the expression of a series of antioxidant and detoxifying enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1)

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- May help support detoxification, liver health and immune function