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N Engl J Med 371(15):13691373

Although a great many chronic, inflammatory diseases are recognised as having an oxidative stress component (223) , the history of treating them with antioxidants such as ascorbate has largely been a litany of failure, with the treatment arm often even giving worse prognoses than the placebo (6,223,489501)

[DOI] [PMC free article] [PubMed] [Google Scholar] [47].Agita A, Alsagaff MT

The lens is suspended in place from tiny ciliary muscles by hundreds of fine ligaments called zonules

C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)