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When carnitine availability is low, sensations of muscle weakness , cramps, muscle discomfort or a feeling of heavy legs may appear, especially with physical activity

According to the National Institutes of Health, though most individuals do not need to make an extra effort to eat foods high in carnitine , some genetic or medical problems (such as angina or intermittent claudication) and certain drugs can prevent the body from producing enough of the nutrient, resulting in a shortage

Insufficient hydration can have negative effects on overall well-being

An evaluation of orally supplemented L-carnitine in premature infants receiving Intralipid 20%