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The endometrium is highly responsive to cyclic changes in the ovarian steroid hormones estradiol and progesterone, which largely exert their effects via their cognate nuclear receptors and downstream regulation of gene transcription within multiple cellular compartments of the endometrium (Jain et al., 2022)

doi: 10.1159/000247421 [DOI] [PubMed] [Google Scholar] 60.Undurti A, Huang Y, Lupica JA, Smith JD, DiDonato JA, Hazen SL

This approach works in both a targeted and non-targeted mode, depending on the objective of the study

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doi: 10.1093/cvr/cvaf068

We had a lot of tough treatment choices and investigations to make but we will further present the most important ones