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The compound has been investigated in preclinical research across cardiac, skeletal muscle, neuronal, and renal models, and has progressed through multiple Phase 3 clinical trials in Barth syndrome and primary mitochondrial myopathy

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Journal of the Academy of Consultation-Liaison Psychiatry

The generic drug also must be therapeutically equivalent

Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]

Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy