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Therefore, elevated GGT expression increases tumor cell resistance to ferroptosis, safeguarding cells from ROS and lipid peroxidation, thus driving tumor cell proliferation, metastasis and chemotherapy drug resistance (85,107)

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Approximately 40% of colon cancer patients have KRAS mutations, and patients with KRAS G13D have a poor prognosis, including susceptibility to metastasis and short survival time, while anti-EGFR therapy offers little benefit

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