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Studies with congenitally leptin-deficient, severely obese subjects revealed that administration of physiological doses of leptin decreased food intake and body weight (7)

Notably, studies highlight the insulin-potentiating action associated with the N-terminal region, while amino acids 108-129 elicit high mitogenic responses

Psyllium has been associated with allergic reactions, including anaphylaxis

Most obesity drugs may suppress appetite or food absorption, but only few actually stimulate fat metabolism like the peptide AOD-9604, which has also been tested as an obesity drug in humans

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