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IHH-4 and GLAG-66 cells were treated with 0, 1, 5, 10, 25, 50, 100, 200, 500 and 1000 g/mL of APS for 24, 48 and 72 h to detect the IC50 of APS

Trx becomes oxidized in the process and is regenerated by thioredoxin reductase using NADPH

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Each tablet contains 500 mg of glutathione

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In addition to this, another limitation of the use of NAC is the oral drug bioavailability: oral administration is reported to lead to NAC concentrations below 15 M in the circulation whereas intravenous injections of NAC achieve serum concentrations between 100 and 1500 M [27]