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Conjugation with the ligands that specifically interact with the targeted receptors, those on the BBB and neurons (e.g., folate, lactoferrin, transferrin, insulin, and LDL receptors), enhances the BBB penetration, neuron-targeting efficiency (Guo et al., 2020), and also increases drug bioavailability in the CNS (Gopalan et al., 2020
The KPV benefits profile explores the full anti-inflammatory mechanism, and its gut-healing effects are additionally relevant for neuropathy patients with concurrent gastrointestinal symptoms
BBB between the two compartments of blood circulation and CNS comprises of various complex multicellular structures
2022;23:e4248
[3] Grigor'ev VV, Ivanova TA, Kustova EA, Petrova LN, Serkova TP, Bachurin SO
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