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141,142 ERS-induced apoptosis in cells is largely dependent on increasing CHOP and decreasing BCL-2, while activation of IKK and JNK1 by IRE1 binding with TRAF2 also promotes mitochondria-mediated apoptosis in cells 37,58,59 (Fig

The treatment of Rhodiola Mimics exercise to resist high-fat diet-induced muscle dysfunction via Sirtuin1-dependent mechanisms

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Because of its deacetylase activity, which is based on the ratio of NAD+/NADH, SIRT1 is known as a nutrition sensor 69 .SIRT1 is the sirtuin family member who has drawn the greatest attention