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The effect of probiotic supplementation in alleviating symptoms of five major mental illnesses: a comprehensive review

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(158) demonstrated that colonization of germ-free (GF) mice with a cocktail of 46 Clostridium (primarily belonging to clusters IV and XIVa ) robustly increases Foxp3+ Treg numbers in the colonic lamina propria (LP) without affecting small intestinal Tregs

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This is in stark contrast to protocols which advocate longer injection intervals, which ultimately lead to far greater variations in peaks and troughs