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SERT HVA: 4-Hydroxy-3-methoxyphenylacetic acid, Homovanillic acid i.p.: Intraperitoneal ICV: Intracerebroventricular i.v.: Intravenous K e : Elimination constant KO: Knockout LSD: Lysergic acid diethylamide MAO: Monoamine oxidase MAOi: Monoamine oxidase inhibitor MDA: ()-3,4-Methylenedioxyamphetamine MDEA: Methylenedioxyethylamphetamine MDMA: ()-3,4-Methylenedioxymethamphetamine, Ecstasy -MeDA: -Methyldopamine, 3,4-Dihydroxyamphetamine, HHA METH: Methamphetamine 4-MTA: 4-Methylthioampethamine mtDNA: Mitochondrial DNA MPT: Mitochondrial permeability transition NA: Noradrenaline NAC: N-Acetylcysteine NAT: Noradrenaline transporter NMDA: N -methyl-d-aspartic acid N-Me--MeDA: N -methyl--methyldopamine, 3,4-Dihydroxymethamphetamine, HHMA NO : Nitric oxide radical O 2 : Superoxide anion ONOO : Peroxynitrite PET: Positron emission tomography PD: Pharmacodynamic PK: Pharmacokinetic PKC: Protein kinase C p.o.: Per os PMA: p -Methoxyamphetamine RNS: Reactive nitrogen species ROS: Reactive oxygen species s.c.: Subcutaneous -SH: Sulfhydryl SPECT: Single-photon emission computed tomography SOD: Superoxide dismutase SULT: Sulfotransferase t 1/2 : Elimination half-life TH: Tyrosine hydroxylase THC: 9 -Tetrahydrocannabinol T max : Median time to maximum concentration TPH: Tryptophan hydroxylase UGT: UDP-glucuronosyltransferase UK: United Kingdom USA: United States of America VMAT: Vesicular monoamine transporter WT: Wild type References Abourashed EA, El-Alfy AT, Khan IA, Walker L (2003) Ephedra in perspective-a current review

And then that launches a whole host of metabolic changes, which leads to mitochondrial autophagy, which leads to the intracellular contents of the mitochondria going outside the cell, which creates another whole pro inflammatory response, and then the body stays in the so called Cell danger response never being unstuck, because the triggers are never addressed, and the metabolic machinery is never addressed

Eventually, at high glucose levels, OS induction through regulating the protein kinase C (PKC), glycolysis, hexosamine, polyols pathway, and advanced glycation end products (AGE)

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