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A study evaluating the effect of a pulsatile vs continuous iv administration of hGH in GH-deficient patients (38) found that eight boluses (given at 3 h intervals starting at 8:00 pm) or a continuous infusion of a fixed total hGH dose were equally effective in generating an increase in IGF-1, whereas the same amount of hGH given as two large boluses (at 8:00 pm and 2:00 am) resulted in a significantly smaller increase in IGF-1

A 2017, 121 , 699 707, DOI: 10.1021/acs.jpca.6b1099051Prediction of pKa Values for Druglike Molecules Using Semiempirical Quantum Chemical MethodsJensen, Jan H

These studies highlight how calcium signaling is perturbed under conditions of TBI to impair physiological properties of neurons

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