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In CYB5R3-deficient conditions, MetHb builds up, glutathione (GSH) levels rise in response to oxidative stress, and RBCs display morphological changes such as microcytosis, acanthocytosis, and increased membrane fragility ( Due to the lack of mitochondria, RBCs depend on the pentose phosphate pathway (PPP) to produce reducing equivalents in the form of NADPH

Interestingly, pyruvate kinase liver and red blood cell (PKLR) expression is inhibited in liver-specific Keap1 -null mice [82]

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Glutathione contributes nothing to that process

Neben Glukose knnen die Ketonkrper (die Energie, welche aus den Fettzellengewonnen wird) ebenfalls dazu dienen, das Hirn mit Energie zu versorgen