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While those data reinforce the existence of OR dimers (Massotte, 2014), one should keep in mind that the non-physiological conditions (i.e., detergents and modified receptors) used for such crystallographic studies could generate artifactual interactions

Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds

Jenssen B, Camenga D

The first study showed that the human peptide transporter can be effectively inhibited using a modified CD-based polyrotaxane system 77