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When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]

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Urology 64 , 10101013 (2004)

This elegant therapeutic approach sees its efficacy, however, crippled by several factors: (i) the number of nanoparticles that accumulate in the tumor is usually low due to a reduced targeting efficiency 5 , (ii) the properties of the tumor microenvironment limit the generation of ROS, and (iii) the optical properties of the tissues drastically reduce the amount of light that can reach the NPs housed intratumorally 6