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Furthermore, TAMs can utilize glutamine to drive an M2-like polarization state, which promotes tumor growth and immune evasion (106)

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Metabolic genes that are targets for HIF-1 include LDHA [encoding the M (muscle) form of lactate dehydrogenase), SLC2A1 (encoding GLUT1), PDK1 (encoding pyruvate dehydrogenase kinase 1), FASN (encoding fatty acid synthase), and ACACA (encoding acetyl-CoA carboxylase 1)

Stagnant mucus is more prone to infection, and infection in turn causes more swelling narrowing the pathway further

Rosen et al ., 2003)