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2400022047, YD), and the Natural Science Foundation of Liaoning Province (Grant no

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Spire-type Actin Nucleation Factor 1C (Spire1C) binds INF2 and promotes actin assembly on mitochondrial surfaces and isrupting either Spire1C actin- or formin-binding activities reduces mitochondrial constriction and division (Manor et al., 2015)

Geographically isolated population This 36-year-old woman presents with early-onset invasive ductal carcinoma of the breast associated with a specific BRCA2 mutation that is highly prevalent in her country of origin