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AdoCbl binding allosterically affects BV affinity, with the BV dissociation constant decreasing ~10-fold from K d ~ 7 M to ~0.7 M in the presence of AdoCbl (Fig

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Some studies suggest a zinc deficiency is a cause of subclinical hypothyroidism, which may slow metabolism and contribute to unexplained weight gain and fatigue

10.1371/journal.pmed.1002773 184 SullivanO.PoitevinF.SierraR

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