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Jimmy made allowances for his symptoms at first, chalking them up to the physical demands of his job

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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

This means subcutaneous injections are often used when other administration methods might be less effective

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31 RubensteinR.ChangB.YueJ