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This means the volume you inject for the same dose can differ significantly
If you have to deal with anxiety or chronically stressful situations you need more vitamin B12 than usual

In blood pressure studies, the peptide did not affect basal blood pressure but counteracted both L-NAME-induced hypertension and L-arginine-induced hypotension

When absorption issues are a factor, recovery from a deficiency may take longer, unless B12 is supplied directly through injections

Folate, particularly methylfolate, can worsen this by further increasing SERT and dopamine transporter (DERT) activity, potentially leading to increased anxiety, OCD-like symptoms, emotional instability, and cognitive rigidity
