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As oligodendrocytes are the primary iron-containing cells in the brain and play a crucial role in maintaining iron homeostasis for myelin synthesis through the expression of transferrin and ferritin [182], their degeneration can release excess iron into the local environment, potentially exacerbating oxidative damage and ferroptosis

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Endothelial dysfunction is often an initial phase of vascular damage that may progress to more severe conditions like atherosclerosis in systemic vasculature

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In addition, the outcome of IGF-1 LR3 administration on test subjects depends on factors like age, metabolism, exercise regimen, current overall health condition, and diet

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