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The dopaminergic neurons in the substantia nigra possess dense axonal arborizations and because of their continuous pacemaking activity they are under high mitochondrial stress

Consistent with this, the majority of detected DAG species were significantly lower in livers of GSH-depleted mice under HFD conditions (Figure 4D)

Farsi F, Ebrahimi-Daryani N, Golab F, Akbari A, Janani L, Karimi MY, et al

[DOI] [PubMed] [Google Scholar] 244

Phospholipids are metabolized, utilized, or excreted

46,47 It directly scavenges ROS and upregulates the expression of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), reducing oxidative damage and SASP accumulation in immune cells