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Cytotoxicity [edit] Several studies have demonstrated that the presence of TcdB in mammalian cells leads to rapid changes within cell morphology and cell signaling

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Supporting this mechanism, studies in animal models demonstrate that L-carnitine administration increases the expression of mitochondrial superoxide dismutase-2 (SOD2), reduces markers of inflammation, and alleviates overall oxidative burden (63)

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(i) An unknown transmembrane protein could be interacting with the toxins and be involved in this signalling, somewhat similar to what is known for many protein receptors in the plasma membrane

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This factor kills Trypanosome brucei and Trypanosome brucei rhdesiense , parasites that cause sleeping sickness, through creating ionic pores in endosomes (860-862)

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These spots also go under the name of liver spots, senile lentigines or solar lentigines

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ON LEVERAGING TUCK RESOURCES At Tuck, Ive been fortunate to utilize the alumni network to develop invaluable relationships

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