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182 Generally, PI3K-induced generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP 3 ) results in stimulation of the canonical AKT pathway, which promotes the upregulation of mammalian target of rapamycin complex 1 (mTORC1) signaling

reported that the injection of human NSCs in the lateral ventricles of aged rats improved cognitive function in aged animals as a result of the ability of the transplanted NSCs to differentiate into neuronal lineages in the hippocampus including neurons and astrocytes [205]

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10.1136/bmj.l4898 [DOI] [PubMed] 20.Wells G, Shea B, OConnell D et al (2004) The NewcastleOttawa Scale (NOQAS) for assessing the quality of non-randomized studies in meta-analysis