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In recent years, there has been an increasing interest in the role of PR in the acute setting (either during or shortly after a hospital admission for ECOPD)

It does this by reducing the damage caused by oxidative stress, which is caused by free radicals

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GSR is constitutively present in most cells, but can be induced in an Nrf2-dependent manner under oxidative stress, and it plays a crucial role in preserving the cellular redox state via the regeneration of GSH [62]