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(PubMed) Reeves MA, Hoffmann PR

L-theanine and other alkyl amines are absorbed by peripheral blood mononuclear cells (PMBC) and specifically inhibit the activity of fartnyl pyrophosphate (FPP) synthetase in the MEP, leading to the accumulation of IPP located upstream of the signaling pathway

Furthermore, the activity levels of antioxidant enzymes were significantly reduced in PV patients, although there were no differences in GSH-Px levels [101]

Recruitment for Phase III clinical trials to assess the efficacy and safety of bepirovirsen is also underway, with results expected in early 2026 (NCT05630807 and NCT05630820)