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While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Khezeli M

Epub 2018 Sep 13

On the first visit, his vital signs were: blood pressure 149/85 and pulse 80 bpm

In a systematic review (18 studies, n=6407), there was sufficient evidence to support that duloxetine (60120 mg) provides greater than 50% pain relief at 12 weeks in those with diabetic neuropathy [63]

A recent example of leveraging RWE in an FDA decision is its 2023 approval expanding RECELL labeling for soft tissue reconstruction