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Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model

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We summarized that autophagy is triggered by ROS including iron accumulation-mediated ROS and lipid-based ROS in ROS-dependent ferroptosis and then acts to amplify iron accumulation and lipid peroxidation and subsequently can induce autophagic cell death under specific conditions

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This is particularly important in thalassemia, because a patient with transfusion-related iron burden cannot be handled in the same way as a weak but non-transfusion-dependent patient