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Lastly, our group and others have implemented epigenetic manipulation in the form of pharmacological DNA hypomethylation to generate iTregs of defined phenotype and stable regulatory character [41,42,43,44]

Ca 2+ spiking also differentially activates transcription factors, directly regulating extensive defense gene expression (Dolmetsch et al., 1997

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10.1016/j.bbagen.2015.10.014 84 StrangeR

Circulating free methylated tumor DNA markers for sensitive assessment of tumor burden and early response monitoring in patients receiving systemic chemotherapy for colorectal cancer liver metastasis

has received research grants from Medtronic, CSA Medical, C2 Therapeutics, CDx Medical, EndoStim and Interpace Diagnostics and has served as a consultant for Pfizer, Boston Scientific and Shire