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In the classic CUMS animal model of depression, nasal administration shortened forced swimming and tail suspension times compared to oral administration

In another study, the SHRs with HHcy receiving folate at a dose of 0.4 mg/kg/day for 8 weeks showed a reduction in oxidative stress, as evidenced by decreased malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) levels [77]

10.2174/092986707780831078 64 WandeY.jieL.aikaiZ.yaguoZ.linlinZ.yueG.et al (2020)

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[DOI] [PubMed] [Google Scholar] 26.Anand U., Otto W.R., Anand P

As indicated above, primer synthesis involves activities of the POLRMT and PRIMPOL encoded proteins