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Superoxide radical can be generated by specialized enzymes, such as the xanthine or NADPH oxidases, or as a by-product of cellular metabolism, particularly the mitochondrial electron transport chain, and are converted to hydrogen peroxide by the superoxide dismutase (SOD)

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Small amounts of polyphenols could be antioxidants, enhancing the survival of normal or stressed cells, but at higher concentrations tend to be pro-oxidants, causing apoptosis in cancer cells

Elevated LCACs levels exacerbate stroke injury, while their reduction mitigates damage [100]

For example, in high grade glioma, a Cochrane Review concluded that anti-angiogenic drugs do not improve significantly overall survival and there are no evidences to support this therapeutic approach [19]